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antithyroid agent
Indications:
- treatment of hyperthyroidism, thyrotoxicosis [1]
Monitor:
- thyroid function every 3 months
a) serum TSH
b) serum T4 &/or free T4
- prothrombin time every 3 months
Adverse effects:
- use during the first trimester of pregnancy associated with increased risk for congenital malformations [2]
Mechanism of action:
- agents that inhibit the action, release or production of thyroid hormone
Interactions
drug adverse effects of antithyroid agent(s)
monitor with antithyroid agents
Specific
methimazole; thiamazole (Tapazole)
propylthiouracil (PTU)
General
thyroid agent
References
- Deprecated Reference
- Seo GH, Kim TH, Chung JH
Antithyroid Drugs and Congenital Malformations: A Nationwide
Korean Cohort Study.
Ann Intern Med. 2018. Jan 23
PMID: 29357398
http://annals.org/aim/article-abstract/2670322/antithyroid-drugs-congenital-malformations-nationwide-korean-cohort-study
- Vicente N, Cardoso L, Barros L, Carrilho F.
Antithyroid Drug-Induced Agranulocytosis: State of the Art on Diagnosis and Management.
Drugs R D. 2017 Mar;17(1):91-96. Review.
PMID: 28105610 Free PMC Article