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anti-Ri antibody (type-2 ANNA)

Etiology: 1) cerebellar ataxia 2) myelopathy 3) opisthotonus-myoclonus - paraneoplastic opsoclonus myoclonus 4) other brain stem disorders 5) associated malignancy a) breast cancer b) gynecologic cancer c) small cell lung carcinoma Pathology: Neuronal antigen: -> CNS neuronal nuclei a) NOVA1 b) NOVA2 c) p55 & p80 Laboratory: Antibody directed against 55 kD RNA-binding protein in motor system neurons.

Related

neurooncologic ventral antigen-2 (NOVA-2, astrocytic NOVA-1 like protein, ANOVA) RNA-binding protein Nova-1; neuro-oncological ventral antigen 1; onconeural ventral antigen 1; paraneoplastic Ri antigen; ventral neuron-specific protein 1 (NOVA1)

General

paraneoplastic autoantibody antineuronal nuclear antibody (ANNA)

References

  1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 651
  2. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 625
  3. Stuve O & Zamvil SS. In: Medical Immunology 10th edition (2001), Section 3, Clinical Immunology. 38. Neurologic diseases
  4. Mini Panel of 2 tests: Neuronal Nuclear Antibody IgG, Anti-Hu . Neuronal Nuclear Antibody IgG, Anti-Ri Laboratory Test Directory ARUP: 51088
  5. Panel of 4 tests Laboratory Test Directory ARUP: 51090