anti-rheumatoid arthritis-associated antigen (RANA)

Etiology: - originally found in patients with a) Sjogren's syndrome b) rheumatoid arthritis - the antigen is also detected in B cells infected with Epstein Barr virus Pathology: - nuclear distribution in a finely speckled pattern by immuno-fluorescence microscopy. Clinical significance: - anti-RANA is detected in 90% of patients with rheumatoid arthritis & in 6-25% of control subjects

Related

rheumatoid arthritis (RA) Sjogren's syndrome (autoimmune epitheliitis)

References

Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1020