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anti-Purkinje cell antibody (anti-Yo)
Found in women with paraneoplastic cerebellar degeneration.
Etiology:
- associated with:
1) ovarian carcinoma
2) fallopian tube carcinoma
3) endometrial carcinoma
4) breast carcinoma
5) lymphoma (less frequently)
NOT found in:
1) men with paraneoplastic cerebellar degeneration
2) women with gynecologic cancer without neurologic syndrome
Laboratory:
- Purkinje cell Ab in body fluid
- antibody directed against 34 & 62 kD leucine-zipper proteins.
- neuronal antigen:
-> Purkinje cell cytoplasmic proteins
a) p34 CDR34
b) p62 CDR62-1
c) p62 CDR62-2
Special laboratory:
- exploratory laparotomy indicated for women with anti-Yo & without laboratory-proven cancer
Related
anti-Purkinje cell antibody-2 (anti-PCA-2)
cerebellar degeneration-related antigen 1; CDR34 (CDR1)
cerebellar degeneration-related protein 2; paraneoplastic cerebellar degeneration-associated antigen; major Yo paraneoplastic antigen (CDR2, PCD17)
paraneoplastic cerebellar degeneration
Purkinje cell
Purkinje cell cytoplasmic antibody (PCCA)
General
paraneoplastic autoantibody
Database Correlations
OMIM 117340
References
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 651
- Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 625
- Stuve O & Zamvil SS. In: Medical Immunology 10th edition
(2001), Section 3, Clinical Immunology. 38. Neurologic
diseases.