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cANCA (anti-myeloblastin, anti-serine protease 3)

Etiology: 1) >90% positive predictive value for Wegener's granulomatosis 2) other disorders associated with cANCA include: a) Churg-Strauss syndrome (10%) b) microscopic polyangiitis c) idiopathic cresentic glomeruloneophritis (30%) Pathology: 1) directed against myeloblastin (serine proteinase-3) 2) cANCA may play a role in the pathology of Wegener's granulomatosis (see myeloblastin) Compartment: - cytoplasm Laboratory: - cANCA in serum

Related

cANCA in serum; anti-myeloblastin in serum; anti-serine protease 3 in serum myeloblastin; leukocyte proteinase 3; PR-3; PR3; azurophil granule protein 7; AGP7; Wegener autoantigen; P29; C-ANCA antigen; neutrophil proteinase 4; NP-4 (PRTN3, MBN)

General

anti-neutrophil cytoplasmic antibody (ANCA)

References

  1. Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed, WB Saunders, Philadelphia 1995
  2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 782, 847
  3. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1913
  4. Kaiser Permanente Northern Calfornia Regional Laboratory
  5. Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 17. American College of Physicians, Philadelphia 1998, 2012, 2015
  6. Bosch X et al, Antineutrophil cytoplasmic antibodies. Lancet 2006, 368:404 PMID: 16876669