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anti-MysB antibody

Etiology: 1) positive in 80% of patients with Lambert-Eaton mysasthenic syndrome due to lung cancer (small cell carcinoma) 2) generally negative in patients with Lambert-Eaton syndrome secondary to non-lung cancer 3) 36% of patients have no evidence of cancer Pathology: Neuronal antigen: -> beta-2 subunit of presynaptic voltage-gated Ca+2 channel (Lambert-Eaton myasthenic syndrome antigen B)

Related

Lambert-Eaton myasthenic syndrome (LEMS) voltage-dependent L-type Ca+2 channel beta-2; CAB2; Ca+2 channel voltage-dependent subunit beta 2; Lambert-Eaton myasthenic syndrome antigen B; MYSB (CACNB2, CACNLB2, MYSB)

General

paraneoplastic autoantibody

References

  1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 651
  2. Stuve O & Zamvil SS. In: Medical Immunology 10th edition (2001), Section 3, Clinical Immunology. 38. Neurologic diseases