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MDA5 Ab in serum

Indications: - evaluation of dermatomyositis Clinical significance: - associated with interstitial lung disease, cutaneous ulcers, Gottron papules, poor prognosis

Related

interferon-induced helicase C domain-containing protein 1; clinically amyopathic dermatomyositis autoantigen 140 kDa; CADM-140 autoantigen; helicase with 2 CARD domains; Helicard; interferon-induced with helicase C domain protein 1; melanoma differentiation-associated protein 5; MDA-5; murabutide down-regulated protein; RNA helicase-DEAD box protein 116 (IFIH1, MDA5, RH116)

General

serology

References

  1. Charrow A, Vleugels, RA Cutaneous Ulcerations in Anti-MDA5 Dermatomyositis N Engl J Med 2019; 381:465. August 1, 2019 PMID: 31365803 https://www.nejm.org/doi/full/10.1056/NEJMicm1816147
  2. Medical Knowledge Self Assessment Program (MKSAP) 19 American College of Physicians, Philadelphia 2022