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anti-complement C3d antibody
Procedure:
- direct antiglobulin test
Clinical significance:
Coomb's positive anemia
1) anti-IgG & anti-C3d
a) antibodies to glycoprotein antigens
b) systemic lupus erythematosus
2) anti-C3d only
a) cold-agglutinin syndrome (Donath-Landsteiner Ab)
b) most drug-related antibodies
c) IgM antibodies
d) IgG antibodies of low affinity
e) activation of complement by immune complexes
General
autoantibody
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998