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anthracycline
Adverse effects:
- irreversible dilated cardiomyopathy (2%), systolic heart failure directly related to cumulative dose
- increased risk of heart failure at 15 years after anthracycline 2-fold [2]
- cardiotoxicity synergistic with radiation therapy
- atorvastatin reduces cardiac dysfunction in patients treated with anthracyclines [3]
Interactions
drug interactions
drug adverse effects of anthracyclines
Specific
daunorubicin, daunomycin; DNR (Cerubidine, DaunoXome)
doxorubicin (Adriamycin, Rubex)
epirubicin; pidorubicin (Ellence)
idarubicin; 4-methoxydaunorubicin (Idamycin)
valrubicin (Valstar)
General
antibiotic antineoplastic agent
aromatic compound
enzyme inhibitor
Properties
INHIBITS: topoisomerase
References
- Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 19.
American College of Physicians, Philadelphia 2009, 2012, 2015, 2021
- Lou N
Heart Failure Risk Lingers Long After Chemotherapy, Regardless of Dose.
Several-fold higher cardiovascular risk of anthracycline use persists over
two decades.
MedPage Today February 3, 2023
https://www.medpagetoday.com/cardiology/chf/102955
- Larsen CM, Garcia Arango M, Dasari H et al
Association of Anthracycline With Heart Failure in Patients Treated for
Breast Cancer or Lymphoma, 1985-2010.
JAMA Netw Open. 2023;6(2):e2254669
PMID: 36735254 Free article
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800936
- Neilan TG, Quinaglia T, Onoue T et al
Atorvastatin for Anthracycline-Associated Cardiac Dysfunction.
The STOP-CA Randomized Clinical Trial.
JAMA. 2023;330(6):528-536.
PMID: 37552303 PMCID: PMC10410476 (available on 2024-02-08
https://jamanetwork.com/journals/jama/article-abstract/2807988