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lipocortin-1; annexin-A1; ANXA1; calpactin-2; chromobindin-9; phospholipase-A2 inhibitory protein (ANXA1)
Function:
- Ca+2/phospholipid-binding protein
- promotes membrane fusion & is involved in exocytosis
- protein regulates phospholipase A2 activity
- seems to bind from 2-4 Ca+2 with high affinity
- phosphorylated by protein kinase C, EGFR & TRPM7
- phosphorylation results in loss of inhibitory activity
Structure:
- homodimer in placenta (20%); linked by transglutamylation
- a pair of annexin repeats may form one binding site for Ca+2 & phospholipid
- belongs to the annexin family
- contains 4 annexin repeats
Compartment:
- nucleus (putative), cytoplasm
- cell projection, cilium (putative)
- basolateral cell membrane (putative)
- found in the cilium, nucleus & basolateral cell membrane of ciliated cells in the tracheal endothelium (putative)
- found in the cytoplasm of type 2 pneumocytes & alveolar macrophages (putative)
Laboratory:
- annexin 1 Ag in tissue
General
annexin
lipocortin or calpactin
Properties
COMPARTMENT: cytoplasm
cell nucleus
SIZE: entity length = 346 aa
MW = 39 kD
MOTIF: Ser phosphorylation site {S5}
Tyr phosphorylation site {Y21}
Thr phosphorylation site {T24}
Ser phosphorylation site {S27}
Annexin {51-111}
Annexin {123-183}
Annexin {207-267}
MOTIF: Tyr phosphorylation site {Y207}
Annexin {282-342}
Database Correlations
OMIM 151690
UniProt P04083
Pfam PF00191
Entrez Gene 301
Kegg hsa:301
References
- OMIM :accession 151690
- UniProt :accession P04083