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annexin A2; annexin-2; annexin II; lipocortin II; calpactin I heavy chain; chromobindin-8; p36; protein I; placental anticoagulant protein IV; PAP-IV (ANXA2 ANX2 ANX2L4 CAL1H LPC2D)
Function:
- heavy subunit of calpactin 1
- Ca+2-regulated membrane-binding protein
- affinity for Ca+2 is greatly enhanced by anionic phospholipids
- binds two Ca+2 with high affinity
- may be involved in heat-stress response
- heterotetramer containing 2 light chains of S100A10/p11 & 2 heavy chains of ANXA2/p36
- interacts with ATP1B1 & DYSF
- phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface
- may cross-link plasma membrane phospholipids with actin & the cytoskeleton & play a role in exocytosis
Structure:
- a pair of annexin repeats may form one binding site for Ca+2 & phospholipid
- belongs to the annexin family
- contains 4 annexin repeats
Compartment:
- secreted, extracellular space, extracellular matrix
- basement membrane
- melanosome
- translocated from the cytoplasm to the cell surface through Golgi-independent mechanism
General
annexin
lipocortin or calpactin
phosphoprotein
protein subunit
Properties
COMPARTMENT: cytoplasm
golgi
SIZE: entity length = 339 aa
MW = 39 kD
MOTIF: binding site
SITE: 2-24
FOR-BINDING-OF: S100-A10 protein
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S18}
Thr phosphorylation site {T19}
Tyr phosphorylation site {Y24}
Ser phosphorylation site {S26}
Tyr phosphorylation site {Y30}
Annexin {42-102}
Annexin {114-174}
Tyr phosphorylation site {Y188}
Annexin {199-259}
MOTIF: Tyr phosphorylation site {Y199}
Tyr phosphorylation site {Y238}
Annexin {274-334}
MOTIF: Tyr phosphorylation site {Y316}
Tyr phosphorylation site {Y317}
Tyr phosphorylation site {Y318}
Database Correlations
OMIM 151740
UniProt P07355
Pfam PF00191
Entrez Gene 302
Kegg hsa:302
References
- UniProt :accession P07355
- Protein Spotlight; Note: red velvet - Issue 86 of September 2007
http://www.expasy.org/spotlight/back_issues/sptlt086.shtml
Component-of
calpactin 1