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Ankyrin repeat & KH domain-containing protein 1 (multiple ankyrin repeats single KH domain, HIV-1 Vpr-binding ankyrin repeat protein, hMASK, ANKHD1, KIAA1085, MASK, VBARP, PP2500)
Function:
- may play a role as a scaffolding protein
- isoform 2 may possess an antiapoptotic effect & protect cells during normal cell survival through its regulation of caspases
- interacts with PTPN11
- isoform 2 interacts with VPR
Structure:
- belongs to the mask family
- contains 25 ANK repeats
- contains 1 KH domain
Compartment: cytoplasm
Alternative splicing: named isoforms=5
Expression:
- ubiquitous
- high expression in cervix, spleen & brain.
- expressed in hematopoietic cells
- isoform 2 is highly expressed in spleen with almost no expression in muscle & brain
Pathology:
- increased expression in leukemia cells
- may be associated with the abnormal phenotype of leukemia cells
General
ankyrin repeat domain protein (ANKRD)
scaffold protein
Properties
SIZE: entity length = 2542 aa
MW = 269 kD
COMPARTMENT: cytoplasm
MOTIF: glycine-rich region {6-94}
ankyrin repeat
NAME: ankyrin repeat
SITE: 204-233
ankyrin repeat
NAME: ankyrin repeat
SITE: 237-266
ankyrin repeat
NAME: ankyrin repeat
SITE: 271-300
ankyrin repeat
NAME: ankyrin repeat
SITE: 304-333
ankyrin repeat
NAME: ankyrin repeat
SITE: 337-366
ankyrin repeat
NAME: ankyrin repeat
SITE: 371-400
ankyrin repeat
NAME: ankyrin repeat
SITE: 404-433
ankyrin repeat
NAME: ankyrin repeat
SITE: 437-466
ankyrin repeat
NAME: ankyrin repeat
SITE: 470-499
ankyrin repeat
NAME: ankyrin repeat
SITE: 504-533
ankyrin repeat
NAME: ankyrin repeat
SITE: 534-563
ankyrin repeat
NAME: ankyrin repeat
SITE: 567-596
ankyrin repeat
NAME: ankyrin repeat
SITE: 600-629
ankyrin repeat
NAME: ankyrin repeat
SITE: 634-663
ankyrin repeat
NAME: ankyrin repeat
SITE: 667-696
coiled coil {775-852}
ankyrin repeat
NAME: ankyrin repeat
SITE: 1054-1083
ankyrin repeat
NAME: ankyrin repeat
SITE: 1087-1116
ankyrin repeat
NAME: ankyrin repeat
SITE: 1121-1150
ankyrin repeat
NAME: ankyrin repeat
SITE: 1154-1183
ankyrin repeat
NAME: ankyrin repeat
SITE: 1189-1218
ankyrin repeat
NAME: ankyrin repeat
SITE: 1223-1252
ankyrin repeat
NAME: ankyrin repeat
SITE: 1256-1285
ankyrin repeat
NAME: ankyrin repeat
SITE: 1291-1320
ankyrin repeat
NAME: ankyrin repeat
SITE: 1324-1353
ankyrin repeat
NAME: ankyrin repeat
SITE: 1357-1386
coiled coil {1415-1485}
KH domain
SITE: 1695-1759
FOR-BINDING-OF: ribonucleic acid
serine-rich region {1977-2100}
MOTIF: serine residue (SEVERAL)
serine-rich region {2291-2299}
MOTIF: serine residue (SEVERAL)
Database Correlations
UniProt Q8IWZ3
PFAM correlations
References
UniProt :accession Q8IWZ3