ankyrin-3; ANK-3; ankyrin-G (ANK3)

Function: - membrane-cytoskeleton linker - the neural-specific isoforms may participate in maintenance &/or targeting of ion channels & cell adhesion molecules at the nodes of Ranvier & axonal initial segments - neural-specific isoforms may be a constituent of a neurofascin/NRCAM/ankyrin G complex - interacts with RHBG Structure: - contains 23 ANK repeats - contains 1 death domain - contains 1 ZU5 domain Compartment: cytoplasm, cytoskeleton Alternative splicing: named isoforms=2 Expression: - expressed in brain & other tissues - isoform1 is neural-specific

Properties

SIZE: entity length = 4372 aa MW = 480 kD COMPARTMENT: cytoplasm MOTIF: ankyrin repeat NAME: ankyrin repeat SITE: 73-102 ankyrin repeat NAME: ankyrin repeat SITE: 106-135 ankyrin repeat NAME: ankyrin repeat SITE: 139-168 ankyrin repeat NAME: ankyrin repeat SITE: 172-201 ankyrin repeat NAME: ankyrin repeat SITE: 203-230 ankyrin repeat NAME: ankyrin repeat SITE: 234-263 ankyrin repeat NAME: ankyrin repeat SITE: 267-296 ankyrin repeat NAME: ankyrin repeat SITE: 300-329 ankyrin repeat NAME: ankyrin repeat SITE: 333-362 ankyrin repeat NAME: ankyrin repeat SITE: 366-395 ankyrin repeat NAME: ankyrin repeat SITE: 399-428 ankyrin repeat NAME: ankyrin repeat SITE: 432-461 ankyrin repeat NAME: ankyrin repeat SITE: 465-494 ankyrin repeat NAME: ankyrin repeat SITE: 498-527 ankyrin repeat NAME: ankyrin repeat SITE: 531-560 MOTIF: Tyr phosphorylation site {Y533} ankyrin repeat NAME: ankyrin repeat SITE: 564-593 ankyrin repeat NAME: ankyrin repeat SITE: 597-626 ankyrin repeat NAME: ankyrin repeat SITE: 630-659 ankyrin repeat NAME: ankyrin repeat SITE: 663-690 ankyrin repeat NAME: ankyrin repeat SITE: 691-720 ankyrin repeat NAME: ankyrin repeat SITE: 724-753 ankyrin repeat NAME: ankyrin repeat SITE: 757-786 ankyrin repeat NAME: ankyrin repeat SITE: 790-820 ZU5 {977-1084} Ser phosphorylation site {S1454} serine-rich region {1514-1893} MOTIF: serine residue (SEVERAL) threonine-rich region {2242-2245} MOTIF: threonine residue (SEVERAL) glutamate-rich region {2388-2391} MOTIF: glutamate residue (SEVERAL) glutamate-rich region {3200-3206} MOTIF: glutamate residue (SEVERAL) proline-rich region SITE: 3250-3254 MOTIF: proline residue (SEVERAL) serine-rich region {3477-3482} MOTIF: serine residue (SEVERAL) threonine-rich region {3952-3976} MOTIF: threonine residue (SEVERAL) death domain NAME: death domain SITE: 4085-4169 Ser phosphorylation site {S4293}

Database Correlations

OMIM 600465 UniProt Q12955 PFAM correlations Entrez Gene 288