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angiotensin 1-7

Function: 1) opposes the vasoconstrictor & proliferative actions of angiotensin 2 2) ligand for G-protein coupled receptor Mas 3) enhances LTP in CA1 region of hippocampus 4) formed from angiotensin 2 via hydrolysis by ACE2, or from angiotensin 1-9 Expression: - chronic administration of ACE inhibitors increases angiotensin 1-7 levels 10-25 fold

Related

angiotensin-1/renin activity in plasma

General

angiotensin

Properties

COMPARTMENT: extracellular compartment

References

  1. Ferrario CM. Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation. Hypertension. 2006 Mar;47(3):515-21. Epub 2005 Dec 19. PMID: 16365192
  2. Ferreira AJ, Santos RA. Cardiovascular actions of angiotensin-(1-7). Braz J Med Biol Res. 2005 Apr;38(4):499-507. Epub 2005 Apr 13. Review. PMID: 15962175
  3. Hellner K, Walther T, Schubert M, Albrecht D. Angiotensin-(1-7) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas. Mol Cell Neurosci. 2005 Jul;29(3):427-35. PMID: 15950155