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aneuploidy
Cells having a number of chromosomes different from the haploid, diploid or integer multiple of the diploid chromsome number. In humans, other than 23X, 23Y, 46XX, 46XY, 92XXXX, 92XXYY (etc).
Clinical significance:
- aneuploidy may be prognostic marker for range of different cancers
- tumor aneuploidy correlates with markers of immune evasion & with reduced response to immunotherapy [1]
Specific
chromosome 12 aneuploidy
chromosome 13 aneuploidy
chromosome 13+18+21+X+Y aneuploidy
chromosome 15+16+22 aneuploidy
chromosome 18 aneuploidy
chromosome 3+7+17 aneuploidy & chromosome 9p21 deletion
chromosome 6p25, 6q23, 11q, 8q24 & 9p21 aneuploidy
chromosome X & Y aneuploidy
fetal aneuploidy test panel
fetal chromosomal aneuploid genomic sequencing
fetal chromosome 13+18+21+Y aneuploidy
trisomy
General
chromosomal aberration
Properties
References
- Kerr DJ
Overlooked Biomarker May Predict Cancer Immunotherapy Response.
Medscaape. Feb 15, 2018
https://www.medscape.com/viewarticle/892475
- Davoli T, Uno H, Wooten EC, Elledge SJ.
Tumor aneuploidy correlates with markers of immune evasion and
with reduced response to immunotherapy.
Science. 2017 Jan 20;355(6322) pii: eaaf8399
PMID: 28104840 Free PMC Article
Component-of
aneuploidy & chromosomal microdeletions