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anaplastic oligodendroglioma
oligodendroglioma with anaplastic features, corresponds to WHO grade III Anaplastic oligodendroglioma has more favorable prognosis compared to glioblastoma although histological features may be similar in some cases.
Genetics:
Microarray study [2]:
- glioblastoma gene expression: (fold increase)
- vimentin: 2.55
- dCMP deaminase: 2.8 - 4.83
- SH3 domain GRB2-like endophilin B1: 1.8
- mitogen activated protein kinase 4: 5.57
- CD74: 1.89
- dolichyl-diphosphooligosaccharide protein glycosyltransferase: 1.78
- ras homolog gene family member C: 2.1
- lipoma HMGIC fusion partner-like 2: 2.41
- adenylyl cyclase-associated protein: 1.49
- anaplastic oligodendroglioma gene expression: (fold increase)
- ribosomal protein S13: 2.2
- breakpoint cluster region (BCR): 2.64
- angiopoietin-like 2: 3.96
- ribosomal protein L24: 1.81
- ribosomal protein S20: 2.03
- potassium channel, subfamily K member 3 (TASK-1): 2.43
- eukaryotic translation initiation factor 3, subunit 6: 1.76
- ATP binding cassette, subfamily C member 8: 2.16
- phosphodiesterase 8B: 3.4
- amiloride-sensitive cation channel 2, neuronal: 2.77
Interactions
disease interactions
General
malignant glioma
oligodendroglial neoplasm
References
- WHO Classification Tumours of the Nervous System.
Kleihues & Cavenee eds. IARC Press 2000
- Nutt et al. Cancer Research 3:1602-7, 2003
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