ALK tyrosine kinase receptor; anaplastic lymphoma kinase; CD246 (ALK)

Function: - receptor for pleiotrophin - tyrosine-protein kinase activity - role in the normal development & function of the nervous system - phosphorylates almost exclusively at the 1st Tyr of the Y-x-x-x-Y-Y motif Structure: - homodimer. - N-glycosylated - belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily - contains 1 LDL-receptor class A domain - contains 2 MAM domains - contains 1 protein kinase domain Compartment: membrane Expression: - expressed in brain & CNS - expressed weakly in small intestine, colon, prostate & testis Pathology: - chromosomal translocation t(2;5)(p23;q35.1) involving ALK with NPM1 is found in a form of non-Hodgkin lymphoma - chromosomal translocations t(2;11)(p23;p15) involving ALK with CARS & t(2;4)(p23;q21) involving ALK with SEC31A are associated with inflammatory myofibroblastic tumors - chromosomal translocation t(2;17)(p23;q25) involving ALK with ALO17 is associated with anaplastic large-cell lymphoma

Related

anaplastic lymphoma kinase (ALK) antigen in tissue anaplastic lymphoma kinase (ALK) gene rearrangement

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein tyrosine kinase receptor (RTK)

Properties

SIZE: entity length = 1620 aa MW = 176 kD COMPARTMENT: cellular membrane STATE: active state MOTIF: signal sequence {1-18} N-glycosylation site {N169} Ser phosphorylation site {S211} N-glycosylation site {N244} MAM domain {264-427} MOTIF: cysteine residue {*1} (2) MODIFICATION: cysteine residue {*2} cysteine residue {*2} (2) MODIFICATION: cysteine residue {*1} N-glycosylation site {N285} N-glycosylation site {N324} N-glycosylation site {N411} N-glycosylation site {N424} LDL-receptor class A {437-473} MOTIF: N-glycosylation site {N445} MAM domain {478-636} MOTIF: cysteine residue {*1} (2) MODIFICATION: cysteine residue {*2} cysteine residue {*2} (2) MODIFICATION: cysteine residue {*1} N-glycosylation site {N563} N-glycosylation site {N571} N-glycosylation site {N627} N-glycosylation site {N709} N-glycosylation site {N808} glycine-rich region {816-940} MOTIF: N-glycosylation site {N863} N-glycosylation site {N864} N-glycosylation site {N886} N-glycosylation site {N986} transmembrane domain {1039-1059} Tyr phosphorylation site {Y1078} Tyr phosphorylation site {Y1092} Tyr phosphorylation site {Y1096} kinase domain SITE: 1116-1392 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 1122-1130 Tyr phosphorylation site {Y1131} ATP-binding site NAME: ATP-binding site SITE: 1150-1150 aspartate residue {D1249} Tyr phosphorylation site {Y1278} Tyr phosphorylation site {Y1282} Tyr phosphorylation site {Y1283} Tyr phosphorylation site {Y1359} Tyr phosphorylation site {Y1507} Tyr phosphorylation site {Y1584} Tyr phosphorylation site {Y1604}

Database Correlations

OMIM 105590 MORBIDMAP 105590 UniProt Q9UM73 PFAM correlations Entrez Gene 238 Kegg hsa:238 ENZYME 2.7.10.1