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amyloid-beta peptide 42 in CSF

also see Tau/Abeta42 in CSF Clinical significance: - high CSF Abeta42 associated with normal cognition & hippocampal volume despite increasing brain amyloidosis [1] - decreased CSF Abeta42 associated with higher likelihood of Alzheimer's disease (AD) - a decrease in CSF Abeta42 occurs 18 years prior to development of AD [4] - CSF Abeta42 decreased in patients with spontaneous cerebral amyloid angiopathy & Alzheimer's disease vs controls [3] - CSF Abeta42 decreased in patients with spontaneous cerebral amyloid angiopathy vs Alzheimer's disease [3]

Related

A4 amyloid peptide; beta-peptide cerebrospinal fluid Tau/Abeta42 in CSF; amyloid-tau neurodegeneration (ATN) profile

General

amyloid-beta peptide in CSF

References

  1. Sturchio A, Dwevedi AK, Young CB et al High cerebrospinal amyloid-beta 42 is associated with normal cognition in individuals with brain amyloidosis. eClinicalMedicine. 2021. June 28 https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00268-6/fulltext
  2. Elliott Knapp D Novel Biomarker Found for Alzheimer's Disease. Medscape. January 20, 2022 https://www.medscape.com/viewarticle/966918 - Zaretsky DV, Zaretskaia MV, Molkov YI et al Patients with Alzheimer's disease have increased cellular amyloid uptake. medRxiv 2022. Jan 13 https://www.medrxiv.org/content/10.1101/2022.01.12.22269196v1.full
  3. De Kort AM et al. Decreased cerebrospinal fluid amyloid beta 38, 40, 42, and 43 levels in sporadic and hereditary cerebral amyloid angiopathy. Ann Neurol 2023 Jan 27; [e-pub] PMID: 36707720 https://onlinelibrary.wiley.com/doi/10.1002/ana.26610
  4. Jia J et al. Biomarker changes during 20 years preceding Alzheimer's Disease. N Engl J Med 2024 Feb 21; 390:712-722 PMID: 38381674 https://www.nejm.org/doi/10.1056/NEJMoa2310168

Component-of

amyloid-beta peptide 40/42 in CSF (Lumipulse G) phosphorylated tau/Abeta42 in CSF Tau/Abeta42 in CSF; amyloid-tau neurodegeneration (ATN) profile