amphiphysin (AMPH, AMPH1)

Function: - may participate in mechanisms of regulated exocytosis in synapses & certain endocrine cell types - may control properties of membrane associated cytoskeleton - heterodimer with BIN1 - binds SH3GLB1 & AP2A2 - interacts with AP2B1 Structure: - contains 1 BAR domain - contains 1 SH3 domain Compartment: - cytoplasmic vesicle, secretory vesicle - synaptic vesicle membrane - peripheral membrane protein; cytoplasmic side - cytoplasm, cytoskeleton Alternative splicing: named isoforms=2 Expression: - expressed in neurons, certain endocrine cell types & spermatocytes Pathology: - antibodies against AMPH are detected in patients with stiff-man syndrome

General

antigen cytoskeletal protein phosphoprotein

Properties

SIZE: entity length = 695 aa MW = 76 kD COMPARTMENT: cytoplasm MOTIF: Thr phosphorylation site {T6} coiled coil {10-83} BAR {24-240} MOTIF: coiled coil {144-191} Ser phosphorylation site {S250} Ser phosphorylation site {S295} Thr phosphorylation site {T297} Ser phosphorylation site {S506} src homology 3 [SH3] domain SITE: 622-695

Database Correlations

OMIM 600418 UniProt P49418 PFAM correlations Entrez Gene 273 Kegg hsa:273