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AMP-activated protein kinase, acetyl CoA carboxylase kinase or HMG CoA reductase kinase

activated in cells incubated with insulin

Interactions

molecular events

General

multisubunit protein serine/threonine kinase

Properties

STATE: active state MOTIF: S/T phosphorylation site kinase domain MOTIF: ATP-binding site NAME: ATP-binding site SUBUNITS: AMP-activated protein kinase-alpha subunit AMP-activated protein kinase-beta subunit AMP-activated protein kinase-gamma subunit MISC-INFO: RECOGNITION-MOTIF :SEQUENCE MRSSM[S*]GLHL RECOGNITION-MOTIF :SEQUENCE MIHNR[S*]KINL

Database Correlations

OMIM 600497

References

  1. OMIM :accession 600497
  2. Denton RM. Insulin signalling: search for the missing links. Nature. 1990 Nov 22;348(6299):286-7. PMID: 2250701
  3. Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: 2238044

Components

AMP-activated protein kinase-alpha subunit (AMPKa) AMP-activated protein kinase-beta subunit (AMPKb) AMP-activated protein kinase-gamma subunit