Contents

Search

amlodipine/indapamide/telmisartan (Widaplik)

Indications: - initial treatment of hypertension [4] (FDA-approved) Dosage: - telmisartan: 10 mg, indapamide: 0.625 mg, amlodipine: 1.25 mg - telmisartan: 20 mg, indapamide: 1.25 mg, amlodipine: 2.5 mg - telmisartan: 40 mg, indapamide: 2.5 mg, amlodipine: 5 mg Mechanism of action: - angiotensin-2 receptor antagonist, calcium channel blocker, thiazide diuretic combination

General

antihypertensive combination

References

  1. Rodgers A, Salam A, Schutte AE, et al. Efficacy and Safety of a Novel Low-Dose Triple Single-Pill Combination Compared With Placebo for Initial Treatment of Hypertension. J Am Coll Cardiol. 2024 Aug 30:S0735-1097(24)08227-5. PMID: 39217570
  2. Ojji DB, Salam A, Sani MU Low-Dose Triple-Pill vs Standard-Care Protocols for Hypertension Treatment in Nigeria: A Randomized Clinical Trial. JAMA. 2024 Oct 1;332(13):1070-1079. PMID: 39215620 PMCID: PMC11366076 (available on 2025-03-03) Clinical Trial.
  3. Rodgers A, Salam A, Schutte AE et al Efficacy and safety of a novel low-dose triple single-pill combination of telmisartan, amlodipine and indapamide, compared with dual combinations for treatment of hypertension: a randomised, double-blind, active-controlled, international clinical trial. Lancet. 2024 Oct 19;404(10462):1536-1546. PMID: 39426836 Clinical Trial.
  4. Lou N Polypill Approved for Hypertension, Including as Initial Therapy. The pill comes in three doses and contains telmisartan, amlodipine, and indapamide. MedPage Today June 9, 2025 https://www.medpagetoday.com/cardiology/hypertension/115980
  5. U.S. Food and Drug Administration. WIDAPLIK (telmisartan, amlodipine and indapamide) tablets, for oral use: Official prescribing information. June 5, 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/219423s000lbl.pdf

Components

amlodipine (Norvasc, Amlocard, Amvaz) indapamide (Lozol) telmisartan (Micardis)