Search
AML-M4; acute myelomonocytic leukemia
Pathology:
- myelocytic & monocytic differentiation evident
- myeloid elements resemble M2; peripheral monocytosis.
Genetics:
- chromosomal translocation t(5;17)(q33;p11.2) involving SPECC1 with PDGFRB may be a cause of juvenile myelomonocytic leukemia
- chromosomal translocation t(5;11)(q31;q23) involving ARHGAP26 with MLL has been found in a case of juvenile myelomonocytic leukemia
Interactions
disease interactions
Related
core-binding factor [CBF]-beta; polyomavirus enhancer binding protein 2 beta; PEBP2-beta; SL3/AKV core-binding factor beta; SL3-3 enhancer factor 1 beta (CBFB)
Specific
acute myelomonocytic leukemia/AML-M4Eos
juvenile myelomonocytic leukemia
General
acute myeloid leukemia (AML)
Database Correlations
OMIM 607785
References
- Cotran et al Robbins Pathologic Basis of Disease,
W.B. Saunders Co, Philadelphia, PA 1989 pg 726
- Liu et al,
Fusion between transcription factor CBF beta/PEB2 beta and a
myosin heavy chain in acute myeloid leukemia.
Science 261:1041 1993
PMID: 8351518
- Mihova D
Leukemia - Acute
AML not otherwise categorized
Acute myelomonocytic leukemia (FAB AML M4)
Pathology Outlines
http://www.pathologyoutlines.com/topic/leukemiaM4.html