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amiloride-sensitive Na+ channel or lung Na+ channel
Function:
- non voltage-gated Na+ channel
- mediates electrodiffusion of sodium through apical membrane of epithelial cells
- controls resporption of sodium in kidney lung, sweat glands
- role in taste perception
Inhibition:
- inhibited by amiloride
Structure:
- heterotetramer consisting of two alpha, one beta & one gamma subunit
- alternative form with delta, replacing an alpha subunit
Compartment:
- apical cell membrane
General
multisubunit protein
Na+ channel
plasma membrane protein
Properties
COMPARTMENT: plasma membrane
MOTIF: membrane region
ION-PERMEABILITY: Na+
SUBUNITS: amiloride-sensitive Na+ channel subunit alpha
MOTIF: cytoplasmic domain {1-85}
transmembrane domain {86-106}
exoplasmic loop {107-562}
MOTIF: N-glycosylation site {N232}
N-glycosylation site {N293}
N-glycosylation site {N312}
N-glycosylation site {N397}
N-glycosylation site {N511}
transmembrane domain {563-583}
cytoplasmic domain {584-669}
amiloride-sensitive Na+ channel subunit beta
MOTIF: cytoplasmic domain {1-50}
transmembrane domain {51-71}
exoplasmic loop {72-532}
MOTIF: N-glycosylation site {N135}
N-glycosylation site {N141}
N-glycosylation site {N199}
N-glycosylation site {N207}
N-glycosylation site {N260}
N-glycosylation site {N364}
N-glycosylation site {N378}
N-glycosylation site {N449}
N-glycosylation site {N484}
transmembrane domain {533-553}
cytoplasmic domain {554-640}
amiloride-sensitive Na+ channel subunit gamma
MOTIF: cytoplasmic domain {1-55}
transmembrane domain {56-76}
exoplasmic loop {77-541}
MOTIF: N-glycosylation site {N209}
N-glycosylation site {N248}
N-glycosylation site {N271}
N-glycosylation site {N291}
N-glycosylation site {N497}
transmembrane domain {542-562}
cytoplasmic domain {563-649}
Database Correlations
OMIM 601328
References
- OMIM :accession 601328
- Uniprot P51170
Components
amiloride-sensitive Na+ channel subunit alpha; epithelial Na+ channel subunit alpha; alpha-ENaC; SCNEA; nonvoltage-gated Na+ channel 1 subunit alpha; alpha-NaCH (SCNN1A, SCNN1)
amiloride-sensitive Na+ channel subunit beta; epithelial Na+ channel subunit beta; beta-ENaC; ENaCB; SCNEB; nonvoltage-gated Na+ channel 1 subunit beta; beta-NaCH (SCNN1B)
amiloride-sensitive Na+ channel subunit gamma; epithelial Na+ channel subunit gamma; gamma-ENaC; SCNEG; nonvoltage-gated Na+ channel 1 subunit gamma; gamma-NaCH (SCNN1G)