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AMAZE trial

Randomized, double-blind study 1096 patients, uncontrolled on lisinopril 20 mg QD Duration of study: 8 weeks Groups 1) 40 mg of lisinopril QD 2) 20 mg of lisinopril QD plus candesartan 16 mg for 2 weeks, then 32 mg for 6 weeks Results: 1) addition of candesartan improved BP control* better than increasing lisinopril 42.7% vs 36.9% * as measured by blood pressure < 140/90 blood pressure reduction 3.1/1.9 mm Hg better in candesartan group overall blood pressure reductions 9.5-11.6/7.4-8.3 candasartan group 6.2-8.7/5.9-6.2 in the lisinopril only group

General

hypertension clinical trials

References

  1. Izzo JL et al, Antihypertensive efficacy of candesartan-lisinopril in combination vs. up titration of lisinopril: the AMAZE trials. J Clin Hypertens 2005, 7:565 PMID: 15365275