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prothymosin alpha; contains: thymosin alpha-1 (PTMA, TMSA)
Function:
- prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections
- covalently linked to a small RNA of about 20 nucleotides
Structure: belongs to the pro/parathymosin family
Compartment: nucleus
Alternative splicing: named isoforms=2
General
thymosin
Properties
SIZE: entity length = 111 aa
MW = 12 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S2}
Thr phosphorylation site {T8}
Ser phosphorylation site {S9}
Ser phosphorylation site {S10}
Thr phosphorylation site {T13}
Thr phosphorylation site {T14}
acidic region {42-101}
MOTIF: acidic residue (SEVERAL)
Thr phosphorylation site {T107}
Database Correlations
OMIM 188390
UniProt P06454
Pfam PF03247
Entrez Gene 5757
Kegg hsa:5757
References
- UniProt :accession P06454
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/PTMAID44094ch2q37.html
- Entrez Gene :accession 5757