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alpha-synuclein seed amplification assay; CSF alpha-synuclein (SYNTap test)

Indications: - investigational assay for identifying alpha-synuclein pathology in limbic cortex & neocortex (sensitivity 97.8%, specificity 98.1%) - useful for detecting lewy body dementia [1] - CSF useful for detecting Parkinson's disease - sensitivity 92.6%, specificity 90.5% [2,3] - submandibular gland tissue for detecting Parkinson's disease* - sensitivity 73.2%, specificity 78.6% [3] * only 66% of assays for Parkinson's disease were positive for both CSF & submandibular gland [3] Notes: - may be same as or component of alpha-synuclein aggregates in CSF

Related

alpha synuclein aggregates in CSF; real-time quaking-induced conversion (RT-QuIC) alpha-synuclein; non-A beta component of AD amyloid; non-A4 component of amyloid; NACP (SNCA, NACP, PARK1)

General

special chemistry test

References

  1. Arnold MR et al. alpha-synuclein seed amplification in CSF and brain from patients with different brain distributions of pathological alpha-synuclein in the context of co-pathology and non-LBD diagnoses. Ann Neurol 2022 Jul 9; [e-pub] PMID: 35808984 https://onlinelibrary.wiley.com/doi/10.1002/ana.26453
  2. George J Parkinson's Biomarker Shows High Accuracy. Assay identifies hallmark protein and could help diagnose people earlier. MedPage Today April 12, 2023 https://www.medpagetoday.com/neurology/parkinsonsdisease/103990 - Siderowf A, Concha-Marambio L, Lafontant DE et al Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using alpha-synuclein seed amplification: a cross- sectional study. Lancet Neurol. 2023 May;22(5):407-417. PMID: 37059509 https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00109-6/fulltext
  3. Chahine LM, Beach TG, Adler CH et al. Central and peripheral alpha-synuclein in Parkinson disease detected by seed amplification assay. Ann Clin Transl Neurol 2023 Mar 27; [e-pub]. PMID: 36972727 PMCID: PMC10187727 Free PMC article https://onlinelibrary.wiley.com/doi/10.1002/acn3.51753

Component-of

alpha synuclein aggregates in CSF; real-time quaking-induced conversion (RT-QuIC) alpha synuclein aggregates in skin