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alpha synuclein aggregates in skin
Indications:
- evaluation of presymptomatic Parkinson's disease
Procedure:
- direct stochastic optical reconstruction microscopy in connection with computational tools to image total & phosphorylated-alpha synuclein in skin biopsies [1]
Clinical significance:
- may help diagnose Parkinson's s disease up to two decades before motor symptoms appear [1]
Related
alpha-synuclein; non-A beta component of AD amyloid; non-A4 component of amyloid; NACP (SNCA, NACP, PARK1)
General
alpha synuclein Ag in tissue
References
- Sade O, Fischel D, Barak-Broner N et al
A novel super-resolution microscopy platform for cutaneous alpha-synuclein
detection in Parkinson's disease.
Front Mol Neurosci. 2024 Sep 4;17:1431549.
PMID: 39296283 PMCID: PMC11409901 Free PMC article.
https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2024.1431549/full
Components
alpha-synuclein seed amplification assay; CSF alpha-synuclein (SYNTap test)