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neurexin alpha (alpha latrotoxin receptor, black widow spider venom receptor)
Neurexins are a family of cell surface proteins expressed exclusively in the central nervous system. At least 6 major neurexins are products of 3 genes, with each neurexin gene containing 2 independent promoters (3). The neurexins encoded by the longer transcripts are termed alpha-neurexins; beta-neurexins are encoded by the shorter transcripts. Alpha-neurexin is the receptor for black widow spider venom.
Properties
GENERAL: neurexin
RELATED: spider bite
COMPARTMENT: synaptic membrane
CELL: neuron
FORM: neurexin alpha
MOTIF: EGF domain {N-TERMINAL} (3)
O-glycosylation site
transmembrane domain
binding site
SITE: C-TERMINAL
FOR-BINDING-OF: synaptotagmin
COMPONENT-OF: molecular complex
References
- Ushkaryov et al Science 257:50 1992
- Hata et al Neuron 10:307 1993
- Ullrich et al Neuron 14:497 1995