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alpha-ketoglutarate dehydrogenase

Function: - catalyzes overall conversion of 2-oxoglutarate to succinyl-CoA & CO2 - contains multiple copies of three enzymatic components: a) 2-oxoglutarate dehydrogenase E1 (DHKTD1) b) dihydrolipoamide succinyltransferase E2 c) lipoamide dehydrogenase E3 Cofactor: Thiamine pyrophosphate (putative)

Interactions

molecular events

Related

citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle

General

citric acid cycle enzyme dehydrogenase ketone oxidoreductase multienzyme complex

Properties

COMPARTMENT: mitochondrial matrix MOTIF: active site

Database Correlations

OMIM 246900

References

  1. UniProt :accession Q9H2G4
  2. OMIM :accession 246900

Components

2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; alpha-ketoglutarate dehydrogenase (OGDH) dihydrolipamide acyltransferase E2 (keto acid dehydrogenase E2, BCATE2 E2 subunit, DBT, BCKAD) lipoamide dehydrogenase (glycine cleavage system L protein, DLD, GCSL, LAD, LADH, PHE3)