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alpha-internexin (alpha-Inx, 66 kD neurofilament protein, neurofilament-66, NF-66, INA)
Function:
1) class-4 neuronal intermediate filament
2) able to self-assemble or co-assemble with neurofilament proteins to form intermediate filaments
3) role in morphogenesis of neurons
4) may form independent structural network without involvement of other neurofilaments
5) may cooperate with NF-L to form filamentous backbone to which NF-M & NF-H attach to form cross-bridges
Structure:
- O-glycosylated
- belongs to the intermediate filament family
Expression:
- expressed predominantly in adult CNS
- expressed in brain as early as 16th week of gestation
- reaches steady state level by the 18th week of gestation
- rat brain alpha-internexin mRNA levels are maximal prior to birth & decline into adulthood, while the converse is seen for NF-L. [1]
- expressed by most if not all developing neurons. [2]
General
neurofilament protein
phosphoprotein
Properties
SIZE: MW = 55 kD
entity length = 499 aa
COMPARTMENT: cytoplasm
CELL: neuron
MOTIF: Head {1-87}
MOTIF: Ser phosphorylation site {S72}
Rod {88-408}
MOTIF: Coil 1A {88-129}
Linker 1 {130-142}
Coil 1B {143-238}
Linker 2 {239-262}
Coil 2 {263-408}
Ser phosphorylation site {S335}
Tail {409-499}
MOTIF: glutamate-rich region {449-454}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 605338
UniProt Q16352
PFAM correlations
References
- Fleigner et al EMBO J 1990 Mar;9(3):749-55
- Cairns NJ, Lee VM, Trojanowski JQ.
The cytoskeleton in neurodegenerative diseases.
J Pathol. 2004 Nov;204(4):438-49. Review.
PMID: 15495240
- UniProt :accession Q16352