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alpha-actinin (ACTN)
Actin filament capping protein; caps + end of F-actin to prevent polymerization. alpha-Actinin is a homodimer that also cross- links actin, binds to integrin, vinculin & PI-3-kinase.
Interactions
molecular events
Specific
alpha-actinin-1; alpha-actinin cytoskeletal isoform; non-muscle alpha-actinin-1; F-actin cross-linking protein (ACTN1)
alpha-actinin-2; alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein (ACTN2)
alpha-actinin-3; alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein (ACTN3)
alpha-actinin-4; non-muscle alpha-actinin 4; F-actin cross-linking protein (ACTN4)
General
actinin
oligomerizing protein
PEST protein
Figures/Diagrams
E-cadherin/CD31 ... F-actin
Properties
CONFIGURATION: dimer
SIZE: MW = 97 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil
PEST region
domain
MOTIF: binding site
FOR-BINDING-OF: integrin-beta
binding site
EFFECTOR-BOUND: alpha-actinin
BOUND-VIA: binding site
binding site
FOR-BINDING-OF: phosphoinositide-3-kinase
binding site
FOR-BINDING-OF: vinculin
binding site
FOR-BINDING-OF: F-actin
EF hand
References
- Clark EA & Brugge JS
Integrins and signal transduction pathways: the road taken.
Science 268:233 1995
PMID: 7716514
- Wang KK et al
Calmodulin-binding proteins as calpain substrates.
Biochem J 262:693 1989
PMID: 2556106
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 886
Component-of
molecular complex