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alpha-1-fetoprotein (AFP) in amniotic fluid

Also see alpha-1-fetoprotein in body fluid. Indications: - assess risk of neural tube defect Reference values: - concentration of AFP in maternal Serum & Amniotic Fluid is subject to gestational age. AFP specimen concentration * M O M = Median AFP concentration for gestational weeks * M O M = Multiple of the median AFP values in amniotic fluid: Amniotic fluid AFP values from 699 unaffected, singleton pregnancies expressed as regressed median & multiples of the regressed median (MOM) for gestational weeks 15 to 21 are displayed in the table below: Weeks # Median MOM 2.5 MOM 3.0 MOM 3.5 15 100 14.7 36.8 44.1 51.5 16 100 12.7 31.8 38.1 44.5 17 100 10.9 27.3 32.7 38.2 18 100 9.4 23.5 32.7 32.9 19 99 8.1 20.3 24.3 28.4 20 100 7.0 17.5 21.0 24.5 21 100 6.0 15.0 18.0 21.0 * Weeks: gestational weeks; # numbers of specimens * Median: AFP regressed median ng/mL; MOM: Multiples of regressed Median in ng/mL AFP values have been assigned on the basis of COMPLETE gestational weeks. For example, a specimen obtained on gestational week 18 day 6 is assigned to week 18. Clinical significance: - human serum or plasma & amniotic fluid at 15 to 21 weeks gestation to aid in the detection of fetal open neural tube defects (NTD). Test results when used in conjunction with ultrasonography & amniotic fluid acetylcholinesterase testing are a safe & effective aid in the detection of fetal open NTD. Principle: - see alpha-1-fetoprotein in body fluid Specimen: - see alpha-1-fetoprotein in body fluid

Related

alpha-fetoprotein; alpha-1-fetoprotein; alpha-fetoglobulin (AFP HPAFP) amniotic fluid

General

alpha-1-fetoprotein in body fluid

References

  1. Abbott Laboratories ,Diagnostic Division ,Abbott Park, IL 60064 Tumor Markers, IMx AFP, FEBRUARY 1990.
  2. IMx System Operation Manual, Abbott Diagnostics, a Division of Abbott Laboratories, Abbott Park, IL. 60064, AUGUST 1988.
  3. IMx System Assay Manual, Abbott Diagnostics, a Division of Abbott Laboratories, Abbott Park, IL. 60064, AUGUST 1988.
  4. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
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  6. Panel of 25 tests Laboratory Test Directory ARUP: 80269
  7. Panel of 7 tests Laboratory Test Directory ARUP: 80427
  8. Panel of 17 tests Laboratory Test Directory ARUP: 80434
  9. Panel of 24 tests Laboratory Test Directory ARUP: 81064
  10. Panel of 24 tests Laboratory Test Directory ARUP: 81294