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alpha-1 antitrypsin in serum/plasma (AAT)

Indications: - evaluation of hereditary alpha-1 antitrypsin deficiency - early onset emphysema - evaluation of persistent hyperbilirubinemia or jaundice Specimen: 1) serum, plasma (EDTA) 2) separate serum immediately 3) stable > 7 days at 4 degrees C Reference interval: - 78-200 mg/dL (adult) - 102-254 mg/dL [5] * using cutoff < 85 mg/dL for alpha-1 antitrypsin deficiency - PiZZ phenotype: sensitivity of 99.5%, specificity of 96.5% - PiSZ phenotype: sensitivity of 85.9% [5] Procedure: nephelometry Increases: 1) inflammation 2) surgery, trauma 3) pregnancy, estrogens, oral contraceptive Decreases: 1) nephrotic syndrome 2) terminal hepatic disease or pancreatic disease 3) hereditary alpha-1 antitrypsin deficiency

Related

alpha-1 antitrypsin deficiency alpha-1-antitrypsin; alpha-1 protease inhibitor; alpha-1-antiproteinase; Serpin A1 (SERPINA1, AAT, PI, PRO0684, PRO2209) SERPINA1 gene mutation; alpha-1 antitrypsin gene mutation

Specific

alpha-1 antitrypsin MM in serum alpha-1 antitrypsin MS in serum alpha-1 antitrypsin MZ in serum alpha-1 antitrypsin SS in serum alpha-1 antitrypsin SZ in serum alpha-1 antitrypsin ZZ in serum

General

alpha-1 antitrypsin in body fluid (AAT)

References

  1. Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1995
  2. Alpha-1-Antitrypsin Laboratory Test Directory ARUP: 50001
  3. Panel of 5 tests Laboratory Test Directory ARUP: 51256
  4. Mini Panel of 2 tests: Alpha-1-Antitrypsin . A1A Phenotype Laboratory Test Directory ARUP: 80500
  5. Hurley K, O'Connor GT Serum alpha1-Antitrypsin Concentration in the Diagnosis of alpha1-Antitrypsin Deficiency. JAMA. 2018;319(19):2034-2035. May 15, 2018 PMID: 29800192 https://jamanetwork.com/journals/jama/fullarticle/2681172