alpha-1 adrenergic receptor

A presynaptic heteroreceptor on serotoninergic neurons. Norepinephrine interaction stimulates further release of serotonin. Blockade of alpha-1-adrenergic receptors causes dizziness, hypotension & drowsiness.

Related

alpha-1 adrenergic receptor agonist alpha-1 adrenergic receptor antagonist; prostate-selective alpha blocker gene

Specific

alpha-1A adrenergic receptor; alpha 1A-adrenoreceptor; alpha 1A-adrenoceptor; alpha-1C adrenergic receptor; alpha-adrenergic receptor 1c (ADRA1A, ADRA1C) alpha-1B adrenergic receptor; alpha 1B-adrenoreceptor; alpha 1B-adrenoceptor (ADRA1B) alpha-1D adrenergic receptor; alpha 1D-adrenoreceptor; alpha 1D-adrenoceptor; alpha-1A adrenergic receptor; alpha-adrenergic receptor 1a (ADRA1D, ADRA1A)

Properties

COMPARTMENT: synaptic membrane CELL: neuron MOTIF: exoplasmic domain {N-TERMINAL} ligand-binding site SITE: WITHIN-MEMBRANE-DOMAINS FOR-BINDING-OF: norepinephrine epinephrine transmembrane domain {TM1} transmembrane domain {TM2} transmembrane domain {TM3} transmembrane domain {TM4} transmembrane domain {TM5} transmembrane domain {TM6} transmembrane domain {TM7} binding site SITE: C-TERMINAL-CYS EFFECTOR-BOUND: palmitate BOUND-VIA: carboxylate cytoplasmic domain {C-TERMINAL}