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5-lipoxygenase (arachidonate-5-lipoxygenase, ALOX5)
Function:
1) catalyzes 1st & 2nd steps of leukotriene synthesis
2) may play a role in actin polymerization
3) Ser phosphorylation by MAPKAPK2 is stimulated by arachidonic acid Cofactors: Fe+2, Ca+2, ATP
Structure:
- belongs to the lipoxygenase family
- contains 1 PLAT domain
Compartment:
- cytoplasm, peripheral membrane
- Ca+2 binding promotes binding to membranes
Interactions
molecular events
Related
lipoxygenase cascade
General
lipoxygenase (arachidonate lipoxygenase, ALOX)
phosphoprotein
Properties
SIZE: entity length = 674 aa
MW = 78 kD
COMPARTMENT: cytoplasm
MOTIF: PLAT {2-118}
MOTIF: Ca+2-binding site
SITE: 17-17
Ca+2-binding site
SITE: 18-18
Ca+2-binding site
SITE: 19-19
Ca+2-binding site
SITE: 44-44
Ca+2-binding site
SITE: 45-45
Ca+2-binding site
SITE: 47-47
Ca+2-binding site
SITE: 79-79
Ca+2-binding site
SITE: 80-80
Ser phosphorylation site {S272}
Iron [Fe]-binding site
SITE: 368-368
Iron [Fe]-binding site
SITE: 373-373
Ser phosphorylation site {S524}
Iron [Fe]-binding site
SITE: 551-551
Iron [Fe]-binding site
SITE: 555-555
Iron [Fe]-binding site
SITE: 674-674
Database Correlations
OMIM 152390
UniProt P09917
PFAM correlations
Entrez Gene 240
KEGG correlations
ENZYME 1.13.11.34
References
- UniProt :accession P09917
- Clark EA & Brugge JS
Integrins and signal transduction pathways: the road taken.
Science 268:233 1995
PMID: 7716514
- Atlas of genetics & cytogenetics in oncology & Haematology
http://atlasgeneticsoncology.org/genes/ALOX5ID42985ch10q11.html