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urinary alkalinization (alkaline diuresis)
Indications:
- salicylate toxicity
- hyperuricemia, tumor lysis syndrome
- cystinuria
- facilitates urinary excretion of acidic pharmaceuticals & toxins
- chlorpropamide
- diflunisal,
- fluoride
- methotrexate
- phenobarbital
- salicylate (herbicide)
- mecoprop (herbicide)
Procedure:
- administration of intravenous sodium bicarbonate to produce urine with a pH >= 7.5
Management:
- increased intake of fruits & vegetables
- decreased protein intake
- NaHCO3 or potassium citrate
Related
urinary acidification
General
clinical procedure
References
- Proudfoot AT, Krenzelok EP, Vale JA
Position Paper on urine alkalinization
J Toxicol Clin Toxicol. 2004;42(1):1-26. Review.
PMID: 15083932
- Goldfarb DS
Urinary alkalinization
Cysteinuria Support Network
http://www.cystinuria.com/articles/urinary-alkalization/
- Chander B and Obligado S
Tumor Lysis Syndrome and the Role of Urinary Alkalinization
Clinical Correlations, The NYU Internal Medicine Blog
http://www.clinicalcorrelations.org/?p=448