Search
activin receptor type-1B; ACTR-IB; serine/threonine protein kinase receptor R2; SKR2; activin receptor-like kinase 4; ALK-4 (ACVR1B, ACVRLK4)
Function:
- on ligand binding, forms a receptor complex consisting of 2 type II & 2 type I transmembrane serine/threonine kinases
- type II receptors phosphorylate & activate type I receptors which autophosphorylate, then bind & activate SMAD transcriptional regulators
- interacts with AIP1
- part of a complex consisting of AIP1, ACVR2A, ACVR1B & SMAD3 (putative)
Cofactor: Mg+2 or Mn+2 (putative)
Structure:
- belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
- contains 1 GS domain
- contains 1 protein kinase domain
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- expressed in many tissues
- most strongly in kidney, pancreas, brain, lung, & liver
Note: variant in position: 478:R->H
General
activin receptor
activin receptor like kinase (ALK)
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 505 aa
MW = 57 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-23}
N-glycosylation site {N43}
transmembrane domain {127-149}
GS {177-206}
kinase domain
SITE: 207-497
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 213-221
ATP-binding site
NAME: ATP-binding site
SITE: 234-234
aspartate residue {D335}
Tyr phosphorylation site {Y380}
Database Correlations
OMIM 601300
UniProt P36896
PFAM correlations
Kegg hsa:91
References
UniProt :accession P36896