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alpha-1,2-glucosyltransferase ALG10-B (alpha-2-glucosyltransferase ALG10-B, asparagine-linked glycosylation protein 10 homolog B, K+ channel regulator 1, K+ channel, voltage-gated subfamily H member 2, KCNH2, human ether-a-go-go-related gene protein, HERG, ERG1 ALG10B, KCR1)
Function:
1) glycosylation pathway
2) alpha-1,2-glucosyltransferase (putative_
3) adds 3rd glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation
4) transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol
5) when coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2
6) interacts with KCNH1 & KCNH2/HERG
Compartment:
- cell membrane
Expression:
- expressed in heart, placenta, liver, kidney, pancreas > lung, skeletal muscle, brain.
Pathology:
- defects in ALG10B may diminish susceptibility to acquired long QT syndrome
General
glucosyl transferase
transmembrane 12 protein
Properties
SIZE: MW = 55 kD
entity length = 473 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-6}
transmembrane domain {7-27}
exoplasmic loop {28-64}
transmembrane domain {65-85}
cytoplasmic loop {86-97}
transmembrane domain {98-118}
exoplasmic loop {119-126}
transmembrane domain {127-147}
cytoplasmic loop {148-150}
transmembrane domain {151-171}
exoplasmic loop {172-175}
transmembrane domain {176-196}
cytoplasmic loop {197-256}
transmembrane domain {257-277}
exoplasmic loop {278-283}
transmembrane domain {284-304}
cytoplasmic loop {305-317}
transmembrane domain {318-338}
exoplasmic loop {339-365}
transmembrane domain {366-386}
cytoplasmic loop {387-392}
transmembrane domain {393-413}
exoplasmic loop {414-436}
transmembrane domain {437-457}
cytoplasmic domain {458-473}
Database Correlations
OMIM correlations
MORBIDMAP correlations
UniProt Q5I7T1
Pfam PF04922
References
- UniProt :accession Q5I7T1
- GGDB; GlycoGene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp