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aldosterone (Electrocortin, Aldocortin)
Aldosterone secretion from the zona glomerulosa of the adrenal gland is stimulated by angiotensin II. The effect of aldosterone is predominantly on the distal tubular network of the kidney, effecting an increase in Na+ in exchange for K+. Effect mediated via mineralocorticoid receptor.
Aldosterone may have deleterious effects on the myocardium. (see aldosterone antagonist)
Interactions
molecular events
monitor with mineralocorticoids
Related
adrenal steroid biosynthesis
aldosterone in serum/plasma
aldosterone receptor antagonist (aldosterone antagonist)
hyperaldosteronism
hypoaldosteronism; mineralocorticoid deficiency
mineralocorticoid receptor; MR; nuclear receptor subfamily 3 group C member 2 (NR3C2, MCR, MLR)
Specific
tetrahydroaldosterone
General
11 hydroxycorticosteroid
adrenal cortex hormone; corticosteroid
mineralocorticoid
pregnenedione
Properties
SECRETED-BY: epithelial cell
WITHIN: zona glomerulosa
Database Correlations
PUBCHEM correlations
References
Tietz Textbook of Clinical Chemistry, 2nd ed.
Burtis CA & Ashwood ER (eds), WB Saunders Co,
Philadelphia PA, 1993, pg 1519