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aldolase-A (muscle-type aldolase, lung cancer antigen NY-LU-1, ALDOA, ALDA)
Function:
- carbohydrate degradation; glycolysis
- D-glyceraldehyde 3-phosphate & glycerone phosphate from D-glucose: step 4/4
- 50-fold greater activity with fructose 1,6-bisphosphate than fructose-1-phosphate.
D-fructose 1,6-bisphosphate
glycerone phosphate + D-glyceraldehyde 3-phosphate
Structure:
- homotetramer
- belongs to the class 1 fructose-bisphosphate aldolase family
Pathology:
- defects in ALDOA are a cause of hemolytic anemia
General
fructose-1,6 diphosphate aldolase or fructose diphosphate aldolase
phosphoprotein
Properties
CONFIGURATION: tetramer
SIZE: entity length = 364 aa
MW = 39 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S36}
Ser phosphorylation site {S39}
Ser phosphorylation site {S46}
binding site
SITE: 56-56
FOR-BINDING-OF: Substrate
Thr phosphorylation site {T65}
binding site
SITE: 147-147
FOR-BINDING-OF: Substrate
glutamate residue {E188}
Tyr phosphorylation site {Y204}
lysine residue {K230}
Thr phosphorylation site {T235}
Thr phosphorylation site {T241}
Ser phosphorylation site {S354}
Ser phosphorylation site {S356}
substrate preference {364-364}
Database Correlations
OMIM 103850
MORBIDMAP 103850
UniProt P04075
Pfam PF00274
Entrez Gene 226
KEGG correlations
ENZYME 4.1.2.13
References
- Tietz Textbook of Clinical Chemistry, 2nd ed.
Burtis CA & Ashwood ER (eds), WB Saunders Co,
Philadelphia PA, 1993, pg 810
- UniProt :accession P04075
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ALDOA