aldehyde dehydrogenase

Function: - metabolism of acetaldehyde to acetate - 2nd step in ethanol metabolism - metabolism of corticosteroids, biogenic amines, neurotransmitters, & lipid peroxidation Epidemiology: - Asians more frequently than whites deficient in this enzyme

Specific

10-formyltetrahydrofolate dehydrogenase ALDH1L2 (aldehyde dehydrogenase family 1 member L2, ALDH1L2) aldehyde dehydrogenase 1 family, member A1 (ALDH1A1, aldehyde dehydrogenase 1, aldehyde dehydrogenase cytosolic, RalDH1, ALDH-E1, LDC, ALDH1, PUMB1) aldehyde dehydrogenase 1 family, member A2; retinal dehydrogenase 2; retinaldehyde-specific dehydrogenase type 2 (ALDH1A2, RALDH2) aldehyde dehydrogenase 1 family, member A3 (aldehyde dehydrogenase 6, acetaldehyde dehydrogenase 6, RALDH-3, ALDH1A3, ALDH6) aldehyde dehydrogenase 1 family, member B1 (aldehyde dehydrogenase 5, mitochondrial aldehyde dehydrogenase X, ALDH class 2, ALDH1B1, ALDH5, ALDHX) aldehyde dehydrogenase 2, mitochondrial (acetaldehyde dehydrogenase 2, liver mitochondrial aldehyde dehydrogenase, ALDHI, ALDH-E2, ALDH2, ALDM) aldehyde dehydrogenase 3 family, member A1 (aldehyde dehydrogenase 3, acetaldehyde dehydrogenase 3, ALDH3A1, ALDH3) aldehyde dehydrogenase 3 family, member A2 (aldehyde dehydrogenase 10, microsomal aldehyde dehydrogenase, ALDH3A2, ALDH10 FALDH) aldehyde dehydrogenase 3 family, member B1 (aldehyde dehydrogenase 7, ALDH3B1, ALDH7) aldehyde dehydrogenase 3 family, member B2 (aldehyde dehydrogenase 8, ALDH3B2, ALDH8) aldehyde dehydrogenase 4 family, member A1 (aldehyde dehydrogenase 4, pyrroline 5 carboxylate dehydrogenase, ALDH4A1, ALDH4, P5CDH) aldehyde dehydrogenase 5 family, member A1; succinate semialdehyde dehydrogenase; NAD+ dependent succinic semialdehyde dehydrogenase (ALDH5A1, SSADH) aldehyde dehydrogenase 6 family, member A1 (methylmalonate-semialdehyde dehydrogenase, ALDH6A1, MMSDH) aldehyde dehydrogenase 7 family, member A1 (alpha-aminoadipic semialdehyde dehydrogenase, alpha-AASA dehydrogenase, delta1-piperideine-6-carboxylate dehydrogenease, P6c dehydrogenaseantiquitin-1, ALDH7A1, ATQ1) aldehyde dehydrogenase 9 family, member A1 (aldehyde dehydrogenase 9, aldehyde dehydrogenase E3 isozyme, gamma-aminobutyraldehyde dehydrogenase, ALDH9A1, ALDH4, ALDH7, ALDH9) aldehyde dehydrogenase family 8 member A1 (aldehyde dehydrogenase 12, ALDH8A1, ALDH12) formaldehyde dehydrogenase

General

aldehyde lyase (aldolase) dehydrogenase

Properties

MOTIF: active site binding site FOR-BINDING-OF: NAD

Database Correlations

OMIM 100640 ENZYME 1.2.1.3

References

OMIM :accession 100640