alanine aminotransferase (ALT) or glutamine/pyruvate transaminase (GPT)

Function: - interconverts alanine & pyruvate Expression: - ALT is found in significant amounts in liver & kidney Laboratory: - presence in serum is used as an indication of hepatocellular degeneration inflammation (hepatitis) - see ALT in serum

Specific

alanine aminotransferase 1 (ALT1, glutamic-pyruvic transaminase 1, GPT 1, glutamic-alanine transaminase 1, GPT1, AAT1) alanine aminotransferase 2 (ALT2, glutamic-pyruvic transaminase 2, GPT 2, glutamic-alanine transaminase 2, GPT2, AAT2)

Properties

COMPARTMENT: cytoplasm CELL: hepatocyte MOTIF: cofactor-binding site COFACTOR-BOUND: pyridoxal phosphate MISC-INFO: lifetime 35-57 HOURS {1/2-LIFE}

References

- Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 265