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rac-beta serine/threonine kinase (AKT2 kinase, protein kinase B-beta, PKB beta, AKT2)
Function:
- general protein kinase capable of phosphorylating several known proteins
- 2 specific sites, one in the kinase domain (Thr-309) & the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation
Structure:
- belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family, RAC subfamily
- contains 1 AGC-kinase C-terminal domain
- contains 1 PH domain
- contains 1 protein kinase domain
Expression:
- expressed in all human cell types so far analyzed
- highly expressed in insulin responsive tissues
Pathology:
- alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas
- mutation associated with severe insulin resistance & diabetes mellitus in one family [2]
General
rac S/T kinase; AKT kinase
Properties
SIZE: MW = 56 kD
entity length = 481 aa
STATE: active state
MOTIF: PH domain {5-108}
S/T phosphorylation site
kinase domain
SITE: 152-409
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 158-166
ATP-binding site
NAME: ATP-binding site
SITE: 181-181
aspartate residue {D275}
Database Correlations
OMIM 164731
MORBIDMAP 164731
UniProt P31751
PFAM correlations
Entrez Gene 208
Kegg hsa:208
ENZYME 2.7.11.1
References
- UniProt :accession P31751
- George S, Rochford JJ, Wolfrum C, Gray SL, Schinner S et al
A family with severe insulin resistance and diabetes due to a
mutation in AKT2.
Science. 2004 May 28;304(5675):1325-8.
PMID: 15166380
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/AKT2ID517ch19q13.html