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akt proto-oncogene
Human cellular homolog of mouse thymoma oncogene. Chromosomal rearrangements in T-cell leukemias. Found with breakpoint locus containing this gene. Locus frequently affected by translocations in T-cell leukemias & lymphomas. Gene amplified in gastric carcinoma.
Related
rac-alpha serine/threonine kinase (AKT1 kinase, protein kinase B)
General
proto-oncogene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: Akt1 kinase
LOCUS: human chromosome-14 Q32.3
MOTIF: transcription factor binding site
transcriptional start site
exon
intron
transcriptional termination site
Database Correlations
OMIM 164730
MORBIDMAP 164730
References
- Bellacosa A, Testa JR, Staal SP, Tsichlis PN.
A retroviral oncogene, akt, encoding a serine-threonine kinase
containing an SH2-like region.
Science. 1991 Oct 11;254(5029):274-7.
PMID: 1833819
- OMIM :accession 164730