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A-kinase anchor protein 2; AKAP-2; AKAP-KL; protein kinase A-anchoring protein 2; PRKA2 (AKAP2, KIAA0920, PRKA2)
Function:
- binds to regulatory subunit (RII) of protein kinase A may be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify & focus diffuse, trans-cellular signals carried by cAMP (putative)
Structure:
- the RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer
Alternative splicing: named isoforms=5
Related
protein kinase A
General
A-kinase anchor protein
phosphoprotein
Properties
SIZE: entity length = 859 aa
MW = 95 kD
MOTIF: Ser phosphorylation site {S121}
Ser phosphorylation site {S152}
coiled coil {213-290}
Ser phosphorylation site {S324}
Ser phosphorylation site {S393}
Ser phosphorylation site {S411}
Ser phosphorylation site {S461}
Ser phosphorylation site {S479}
PKA-RII subunit binding {566-579}
Ser phosphorylation site {S631}
coiled coil {710-748}
MOTIF: Ser phosphorylation site {S720}
Ser phosphorylation site {S748}
Ser phosphorylation site {S778}
Database Correlations
OMIM 604582
UniProt Q9Y2D5
Pfam PF10522
LOCUS-LINK correlations
KEGG correlations
References
UniProt :accession Q9Y2D5