A-kinase anchor protein 3; AKAP-3; A-kinase anchor protein 110 kD; AKAP 110; cancer/testis antigen 82; CT82; fibrous sheath protein of 95 kD; FSP95; fibrousheathin I; fibrousheathin-1; protein kinase A-anchoring protein 3; PRKA3; sperm oocyte-binding protein (AKAP3 AKAP110 SOB1)

Function: - may function as a regulator of both motility- & head- associated functions such as capacitation & the acrosome reaction - phosphorylated on Tyr - interacts with ROPN1 & ROPN1L Structure: - PKA RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the PKA-R-subunit dimer - belongs to the AKAP110 family Compartment: - cytoplasmic vesicle, secretory vesicle, acrosome (putative) - ribs of the fibrous sheath in the principal piece of the sperm tail - dorsal margin of the acrosomal segment Expression: - testis specific - only expressed in spermatids

General

A-kinase anchor protein myristoylated protein phosphoprotein testis-specific protein

Properties

SIZE: entity length = 853 aa MW = 95 kD COMPARTMENT: cytoplasm MOTIF: PKA-RII subunit binding {124-137} Ser phosphorylation site {S205} Ser phosphorylation site {S208} Ser phosphorylation site {S403} Tyr phosphorylation site {Y404} Ser phosphorylation site {S440} Ser phosphorylation site {S612} Ser phosphorylation site {S635} Ser phosphorylation site {S636}

Database Correlations

OMIM 604689 UniProt O75969 PFAM correlations Entrez Gene 10566 Kegg hsa:10566

References

UniProt :accession O75969