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AIDS-defining condition

Conditions listed in AIDS surveillance case definition: 1) malignancies - Kaposi's sarcoma, especially < 60 years of age - CNS lymphoma, especially < 60 years of age - other non-Hodgkin's lymphoma - invasive cervical cancer 2) Infection a) Pneumocystis pneumonia - Pneumocystis carinii pneumonia (PCP) - Pneumocystis jirovecci pneumonia b) cytomegalovirus (except liver, spleen, lymph nodes) - CMV retinitis (with loss of vision) c) Mycobacterial infection - Mycobacterium avium complex (MAC) - disseminated - involvement of organ(s) other than - lung - hilar or cervical lymph nodes - skin - Mycobacterium kansasii (same as MAC) - Mycobacterium tuberculosis (extrapulmonary > pulmonary) - other extrapulmonary Mycobacteria d) candidiasis - esophagus - bronchi, trachea or lungs e) coccidioidomycosis, disseminated (extrapulmonary)* f) cryptococcus (extrapulmonary) g) cryptosporidiosis, chronic intestinal (> 1 month duration) h) Herpes simplex - chronic ulcers > 1 month's duration - bronchitis, pneumonia or esophagitis of any duration i) histoplasmosis, disseminated (extrapulmonary)* j) isosporiasis, chronic intestinal (> 1 month duration) k) progressive multifocal leukoencephalopathy (PML) l) Salmonella septicemia, recurrent m) Toxoplasmosis of the brain n) pneumonia, recurrent 3) other (may be infectious) - encephalopathy (HIV-related) - wasting syndrome *sites other than cervical or hilar lymph nodes Other conditions not included above: 1) bacillary angiomatosis 2) candidiasis a) oropharyngeal b) vulvovaginal (perisitent, frequent or poorly responsive to therapy) 3) cervical dysplasia -> carcinoma in situ 4) constitutional symptoms lasting > 1 month a) fever > 38.5 degrees C b) diarrhea 5) hairy leukoplakia, oral 6) shingles (Herpes zoster) involving 2 distinct episodes or more than 1 dermatome 7) idiopathic thrombocytopenic purpura (ITP) 8) Listeriosis 9) pelvic inflammatory disease, especially complicated by tuboovarian abscess 10) peripheral neuropathy

Related

Acquired Immuno-Deficiency Syndrome (HIV infection stage 3, AIDS) HIV1 infection; human immunodeficiency virus-1 infection

References

  1. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1792
  2. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009