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HIV1/AIDS-associated hepatobiliary disorder
Etiology:
1) hepatitis B & hepatitis C are common in homosexual men & injection drug users
2) drug-induced hepatotoxicity
3) opportunistic infections
a) Mycobacteria
b) fungi
c) Cytomegalovirus (CMV)
d) toxoplasmosis
e) microsporidiosis
4) neoplasms
5) acalculous cholecystitis & papillary stenosis with sclerosing cholangitis
a) late complication
b) Cytomegalovirus (CMV)
c) cryptosporidiosis
d) microsporidiosis
6) peliosis hepatis due to Bartonella
7) liver-related deaths associated with low CD4 counts [1]
Laboratory:
- blood cultures for enteric pathogens & Mycobacterium avium intracellulare if fever or CD4 count > 50/uL [2]
* see AIDS-associated gastrointestinal disorder for chronic diarrha
Related
Acquired Immuno-Deficiency Syndrome (HIV infection stage 3, AIDS)
HIV1/AIDS-associated gastrointestinal disorder (includes HIV1-associated diarrhea)
Specific
HIV-associated cholangitis
General
complications in patients with HIV1 infection
hepatobiliary disease
References
- The Data Collection on Adverse Effects of Anti-HIV Drugs
Study Group: Liver-related deaths in person effected with
the human immunodeficiency virus: The D:A:D study.
Arch Intern Med 2006k 166:1632
PMID: 16908797
- NEJM Knowledge+ Gastroenterology