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activation-induced cytidine deaminase (cytidine aminohydrolase, AICDA, AID)
Function:
- RNA-editing deaminase involved in somatic hypermutation, gene conversion, & class-switch recombination
- required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses
cytidine + H2O uridine + NH3
Cofactor: Zn+2
Structure:
- belongs to the cytidine & deoxycytidylate deaminase family
Expression:
- strongly expressed in lymph nodes & tonsils
Pathology:
- defects in AICDA are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2
General
metalloprotein
nucleoside deaminase
Properties
SIZE: MW = 24 kD
entity length = 198 aa
MOTIF: Zn+2-binding site
SITE: 56-56
glutamate residue {E58}
Zn+2-binding site
SITE: 87-87
Zn+2-binding site
SITE: 90-90
Database Correlations
OMIM correlations
MORBIDMAP 605257
UniProt Q9GZX7
PFAM correlations
ENZYME 3.5.4.5
References
- UniProt :accession Q9GZX7
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=AICDA
Component-of
activation induced cytidine deaminase/ibuprofen/pseudoephedrine
activation induced cytidine deaminase/benzocaine/cetylpyridinium