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inappropriate sexual behavior

Etiology: - life-long sexual misbehavior - dementia, especially Pick's disease - psychiatric disorder - dopamine agonists - urinary tract infection (frequent manual manipulation of genitals) History: - obtain history from staff & family Laboratory: - prostate-specific antigen in serum - luteinizing hormone in serum - testosterone in serum - urinalysis - liver function tests Management: - behavioral management first line (cognitive behavioral therapy) - separation of victims from perpetrator - pharmaceuticals (none FDA-approved for this purpose) - cholinesterase inhibitors - serotonin reuptake inhibitors - sertraline 25-100 mg QD may reduce libido - paroxetine (potential anticholinergic effect impacting cognitive function) - mirtazapine may be useful if comorbidity of restless legs syndrome [2] - clomipramine 25-100 mg QD if obsessive behavior - cimetidine may be helpful - antiandrogen compounds may also be helpful in men with sexual misbehavior - progesterone start 5 mg PO QD - leuprolide 5-10 mg IM monthly if behavior improves with progesterone * see disinhibition for dosing

Related

disinhibition

General

conduct disorder

References

  1. Annals of Long-Term Care
  2. Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010 - Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022